C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/495 (2006.01) C07D 211/52 (2006.01) C07D 217/04 (2006.01)
Patent
CA 2087032
Novel diphenylmethyl piperazine derivatives of this invention have a chemical structure represented by the following Formula [I]: (see fig. I) wherein R represents (see fig. 2) or (see fig. 3) The compounds have an effect of inhibiting the overcontraction and overextension of the myocardium without being accompanied by a myocardium-inhibiting effect. By using the novel diphenylmethyl piperazine derivatives as an effective ingredient, it is possible to obtain a myocardial necrosis inhibitor which can protect against myocardial necrosis, and a drug for the treatment and prevention of acute myocardial infarction.
Nouveau dérivé de diphénylméthylpipérazine représenté par la formule générale (I) dans laquelle R représente (a) ou (b). Ce dérivé a un effet inhibant l'hypercontraction et l'hyperextension des muscles cardiaques sans avoir, dans le même temps, un effet cardioinhibiteur, de sorte qu'on peut l'utiliser comme substance active pour un inhibiteur de la nécrose du muscle cardiaque et pour un médicament servant à traiter et à prévenir l'infarctus du myocarde aigu.
Akimoto Kouji
Nakajima Tatsuo
Oosawa Tatsushi
Oota Hideo
Takeishi Makoto
Kaneko Noboru
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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