C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/246, 260/452
C12N 9/99 (2006.01) A61K 31/135 (2006.01) A61K 31/15 (2006.01) A61K 31/175 (2006.01) A61K 31/19 (2006.01) A61K 31/22 (2006.01) C07C 251/58 (2006.01)
Patent
CA 1253871
Abstract of the Disclosure: A compound represented by the formula Image (I) wherein R1 represents a hydroxyl group, an alkanoyloxy group or a group of the formula Image in which R2 represents a hydrogen atom or a lower alkyl group, and R3 represents a hydrogen atom, a lower alkyl group, an alkanoyl group, a phenyl group, a carbamoyl group or a thiocarba- moyl group, or a salt thereof. The said compound can be prepared by reacting a compound represented by the formula Image (II) with a compound of the formula NH2-R1 (III) wherein R1 is as defined hereinabove, or a salt thereof, and as required, alkanoylating the resulting compound of formula (I) in which R1 represents a hydroxyl group or an amino group, and as required, convert- ing the resulting compound of formula (I) in which R1 is the group Image into its salt, and is useful for the treatment of inflammation, pain or reheumatism.
492679
Hasegawa Yukio
Mikami Takashi
Miyasaka Katsuhiko
Miyazawa Katsuhiko
Saito Morinobu
Smart & Biggar
Teikoku Hormone Mfg. Co. Ltd.
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