Diphosphonate-derivatized macromolecules

Details Diphosphonate-derivatized macromolecules Diphosphonate-derivatized macromolecules

C - Chemistry, Metallurgy

08

B

530/15, 167/45,

C08B 37/00 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61K 51/04 (2006.01) A61K 51/06 (2006.01) A61K 51/10 (2006.01) C08F 8/40 (2006.01) C08H 1/00 (2006.01)

Patent

CA 1336739

Diphosphonate-derivatized macromolecules, such as proteins, suitable for use as technetium-99m-based scanning agents and as anticalcification agents are disclosed. The scanning agents are prepared by combining Tc-99m in a +3, +4 and/or +5 oxidation state with the diphosphonate-derivatized macromolecules. Also disclosed are pharmaceutical compositions containing these diphosphonate- derivatized macromolecules and methods for scintigraphic imaging using these diphosphonate-derivatized macromolecules labeled with Tc-99m.

512560

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