C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/208, 167/261
C07F 9/30 (2006.01) A61K 31/66 (2006.01) C07F 9/38 (2006.01) C07F 9/547 (2006.01) C07F 9/572 (2006.01) C07F 9/59 (2006.01) C07F 9/60 (2006.01) C07F 9/6506 (2006.01) C07F 9/6509 (2006.01) C07F 9/6533 (2006.01) C07F 9/6544 (2006.01)
Patent
CA 1334409
Diphosphonic acid derivatives of the general formula: Image (I) wherein: R1 is hydrogen or methyl, R2 is hydrogen or methyl, R3 is a hydrogen atom or a C1-C5 alkyl, R4 is hydrogen or methyl, R5 is hydrogen or methyl, R6 is hydrogen, and m and n are or 0 or 1, or R1 and R2, together with the nitrogen atom to which they are attached form a morpholino ring, or R1 and R3, together with the carbon and nitrogen atoms to which they are attached form a pyrrolidine or piperidine ring, or R4 and R6, together with the carbon atoms to which they are attached form a cyclohexyl ring, or R5 and R6, together with the carbon atom to which they are attached form a spirocyclopentane ring, and the pharmacologically compatible, pharmaceutically acceptable salts thereof and the optical isomers thereof; the derivatives display a marked action on calcium metabolism and may be used for treatment of diseases of the skeletal system, for example, osteoporosis, Paget's disease and Bechterew's disease.
604669
Bosies Elmar
Zilch Harald
Boehringer Mannheim Gmbh
Swabey Ogilvy Renault
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