Diphtheria toxin vaccines bearing a mutated r domain

Details Diphtheria toxin vaccines bearing a mutated r domain Diphtheria toxin vaccines bearing a mutated r domain

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/05 (2006.01) A61K 47/48 (2006.01) C07K 14/34 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 9/10 (2006.01) C12N 15/54 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2191239

Diphtheria toxin polypeptides comprising a mutant R binding domain exhibit reduced target cell binding and may be used as vaccines to immunize a mammal against infection by Corynebacterium diphtheria.

Polypeptides de toxine diphtérique comprenant un domaine de fixation R mutant et présentant une fixation limitée aux cellules cibles. Ces polypeptides peuvent s'utiliser en tant que vaccins, afin d'immuniser un mammifère contre une infection provoquée par Corybactérium diphteria.

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