Dipiperazinyl ketones and related analogues

Details Dipiperazinyl ketones and related analogues Dipiperazinyl ketones and related analogues

C - Chemistry, Metallurgy

07

D

C07D 295/192 (2006.01) A61K 31/395 (2006.01) C07D 211/34 (2006.01) C07D 213/74 (2006.01) C07D 217/00 (2006.01) C07D 231/14 (2006.01) C07D 307/68 (2006.01) C07D 333/38 (2006.01) C07D 471/10 (2006.01) C07D 487/10 (2006.01)

Patent

CA 2606004

Dipiperazinyl ketones and related analogues are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).

La présente invention concerne des dipipérazinyl cétones et analogues apparentés, ainsi que des procédés pour leur préparation et utilisation. De manière générale, ces composés peuvent être utilisés pour moduler la liaison de ligands aux récepteurs histaminiques H3 in vivo ou in vitro ; ils sont particulièrement utiles dans le traitement de divers troubles chez les êtres humains, les animaux domestiques et les animaux d~élevage. L~invention concerne des compositions pharmaceutiques et des procédés thérapeutiques, ainsi que des procédés d~utilisation de ces ligands pour la détection des récepteurs histaminiques H3 (p. ex. études de localisation des récepteurs).

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