Dipyrazoles useful as bronchodilators

Details Dipyrazoles useful as bronchodilators Dipyrazoles useful as bronchodilators

C - Chemistry, Metallurgy

07

D

167/238, 260/298

C07D 487/04 (2006.01) A61K 31/415 (2006.01)

Patent

CA 1324607

ABSTRACT OF THE DISCLOSURE A group of variously methyl-substituted benzo[1,2-c:3,4-c']- dipyrazoles, cyclohepta[1,2-c:3,4-c']dipyrazoles, and cyclopenta[1,2-c:3,4-c']dipyrazoles useful as bronchodi- lators are described herein. The compounds are prepared by reacting a 1,3-diketone with hydrazine or methylhydrazine to give tricyclic products optionally followed by catalytic dehydrogenation and/or alkylation with a strong base and methyl iodide to give various other compounds within the scope of the invention.

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