Dipyridamol sustained release forms and processes for the...

A - Human Necessities – 61 – K

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167/164, 167/231

A61K 31/505 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 9/62 (2006.01)

Patent

CA 1148084

Abstract A dipyridamole sustained release formulation comprises a plurality of spheroidal particles, each of the said spheroidal particles comprising: (a) a core containing dipyridamole or a crystallised salt thereof and a physiologically compatible acid substance in a ratio of at least 1 equivalent of acid substance to 1 mol of dipyridamole or crystallised salt thereof; and (b) a coating which surrounds the core, the coating comprising from 50 to 100% by weight of acid-insoluble lacquer soluble in intestinal juices and from 0 to 50% by weight of lacquer insoluble in gastric and intestinal juices, with the proviso that where the lacquer insoluble in gastric and intestinal juices comprises ethyl cellulose, the weight of ethyl cellulose present does not exceed 14% of the total weight of the coating.

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