Direct aminolysis

Details Direct aminolysis Direct aminolysis

C - Chemistry, Metallurgy

07

C

C07C 209/22 (2006.01) C07D 205/04 (2006.01)

Patent

CA 2616539

In some aspects, the present invention provides a method of preparing a compound of the formula (I) comprising reacting a mesylate compound of the formula (II) by direct aminolysis with a reagent comprising ammonia. The reaction is preferably carried out in a solvent, such as an alcohol, and is preferably carried out in a sealed vessel such as a Parr reactor or the like.

La présente invention a pour objet, par certains de ses aspects, un procédé permettant la préparation d~un composé correspondant à la formule (I) comprenant la réaction d~un composé de mésylate de formule (II) par aminolyse directe avec un réactif contenant de l~ammoniaque. La réaction est réalisée de préférence dans un solvant, par exemple un alcool, et de préférence dans un récipient scellé comme un réacteur de Parr ou analogue.

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