Direct compression polymer tablet core

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 31/785 (2006.01)

Patent

CA 2387915

The present invention provides a tablet core which comprises at least about 95 % by weight of an aliphatic amine polymer. The invention also provides a method of producing a tablet core comprising at least about 95 % by weight of an aliphatic amine polymer resin. The method comprises the step of compressing the aliphatic amine polymer to form the tablet core. The tablet core can further include one or more excipients. In this embodiment, the method of producing the tablet core comprises the steps of: (1) hydrating the aliphatic amine polymer to the desired moisture level; (2) blending the aliphatic amine polymer with the excipients in amounts such that the polymer comprises at least about 95 % by weight of the resulting blend; and (3) compressing the blend to form the tablet core. The present invention further relates to a coated tablet comprising an aliphatic amine polymer core wherein the coating is a water based coating.

La présente invention concerne un noyau de comprimé qui comprend au moins environ 95 % en masse d'un polymère d'amine aliphatique. Cette invention concerne aussi un procédé de production de ce noyau de comprimé comprenant au moins environ 95 % en masse d'une résine polymère d'amine aliphatique. Ce procédé consiste à comprimer ce polymère d'amine aliphatique de façon à former le noyau de comprimé. Ce noyau de comprimé peut également comprendre un ou plusieurs excipients. Dans ce mode de réalisation de l'invention, le procédé de production du noyau de comprimé consiste: (1) à hydrater le polymère d'amine aliphatique à un niveau d'humidité souhaité, (2) à mélanger le polymère d'amine aliphatique avec les excipients dans des quantités telles que le polymère représente au moins environ 95 % en masse du mélange résultant, et (3) à comprimer ce mélange de façon à former le noyau de comprimé. Cette invention concerne aussi un comprimé revêtu comprenant un noyau polymère d'amine aliphatique revêtu d'un revêtement à base d'eau.

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