Direct radiolabeling of antibodies and other proteins with...

Details Direct radiolabeling of antibodies and other proteins with... Direct radiolabeling of antibodies and other proteins with...

C - Chemistry, Metallurgy

07

K

C07K 1/13 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) C07B 59/00 (2006.01) C07K 14/52 (2006.01) C07K 14/655 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2065299

Proteins containing one or more disulfide bonds are radiolabeled with radionuclides of technetium or rhenium for use in diagnosis and treatment of a variety of pathologic conditions. Radiolabeling is accomplished by partial reduction of the disulfide bonds of he protein using Sn (II), or using other seducing agents followed by the addition of Sn (II), removal of excess reducing agent and reduction by-products; and addition of a specified amount of pertechnetate or perrhenate reducing agent, such as stan- nous tartrate; with the addition accomplished in such a manner that further reduction of the protein is limited. The,resulting pro- duct may be stored frozen or lyophilized, with radiolabeling accomplished by the addition of pertechnetate ar perrhenate solu- tion.

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