C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 40/06 (2006.01) C12N 15/115 (2010.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2718337
The present invention provides aptamer libraries with pre-defined secondary structures that can be used for oversampled screening for affinity binding. In one embodiment, a multiplex approach is employed to divide the library into degenerate subsets that are immobilized on multiple locations of a solid support such as a microarray chip
La présente invention porte sur des bibliothèques d'aptamères avec des structures secondaires prédéfinies qui peuvent être utilisées pour un criblage sur-échantillonné pour une liaison d'affinité. Dans un mode de réalisation, une approche multiplex est employée pour diviser la bibliothèque en sous-ensembles dégénérés qui sont immobilisés sur de multiples emplacements d'un support solide tel qu'une puce à ADN.
Borer Philip N.
Mcpike Mark P.
Stikeman Elliott Llp
Syracuse University
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