Direct spray-dried drug/lipid powder composition

Details Direct spray-dried drug/lipid powder composition Direct spray-dried drug/lipid powder composition

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/127 (2006.01) A61K 9/72 (2006.01)

Patent

CA 2081474

2081474 9116882 PCTABS00008 The present invention discloses a method for direct spray-drying a solution of lipids and water soluble drug to generate a bulk powder as an alternative to the drying of preformed liposomes. In the present method the lipids are dissolved in a solvent and the water-soluble drug is dissolved in aqueous solvent. The two solutions are combined to form a precipitate-free feed solution which is then spray-dried to generate the bulk powder. Upon rehydration the powder spontaneously forms liposomes having a high drug encapsulation efficiency of approximately 70 %. The direct spray-dried powder is particularly useful for drug administration by inhalation.

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