C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/14 (2006.01) C07D 498/18 (2006.01) C07H 19/24 (2006.01) C12P 17/18 (2006.01) C12P 19/26 (2006.01)
Patent
CA 2051872
26/RJN10 18221 TITLE OF THE INVENTION A DIRECTED BIOSYNTHESIS PROCESS FOR PROLYL-IMMUNOMYCIN ABSTRACT OF THE DISCLOSURE This invention relates to a novel process for producing a new proline derivative of immunomycin (FK-520), designated "prolyl-immunomycin" that has immunosuppressant activity. This process involves directed biosynthesis, a fermentation process in which a cultured Streptomyces organism, e.g. Streptomyces hygroscopicus subsp. ascomyceticus, ATCC 55087, is grown in the presence of proline or its salts as biosynthetic precursors.
Arison Byron H.
Byrne Kevin M.
Dumont Francis
Kahn Jennifer N.
Kaplan Louis
Arison Byron H.
Byrne Kevin M.
Dumont Francis
Goudreau Gage Dubuc
Kahn Jennifer N.
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