C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2417356
Methods are described for mapping a pathway of differentiation of a population of embryonic cells which includes exposing the cells to an exogenous factor and measuring gene expression products that are characteristic of a particular cell type or lineage. Directing differentiation of human embryonic cells relies on dissociated embryoid bodies which are then exposed to one or more exogenous factors to enrich a culture for a particular cell type. The differentiated cells may be used for treating a medical condition in a human. Kits for determining differentiation pathways and screening exogenous factors for their utility in differentiation are provided.
L'invention concerne des procédés pour mapper une voie conductrice de différentiation d'une population de cellules embryonnaires, qui consiste à exposer les cellules à un facteur exogène et mesurer les produits d'expression génique caractéristiques d'une lignée ou d'un type particuliers de cellules. On dirige la différentiation des cellules embryonnaires humaines sur la base des corps embryoïdes dissociés, qui sont ensuite exposés à un ou plusieurs facteurs exogènes afin d'enrichir une culture pour un type de cellules particulier. Les cellules différentiées peuvent s'utiliser pour traiter un état médical chez l'humain. L'invention concerne aussi des kits pour déterminer les voies de différentiation et cribler des facteurs exogènes pour établir leur utilité.
Oyen Wiggs Green & Mutala Llp
Yissum Research Development Company
LandOfFree
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