Directly compressed solid dosage particles

Details Directly compressed solid dosage particles Directly compressed solid dosage particles

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2407140

Solid dosage articles such as pharmaceutical tablets for the controlled release of a desired compound such as an active ingredient are directly compressed from a flowable, compressible mixture of the active ingredient, a slightly cross-linked rheology modifying polymer or copolymer, and one or more excipients. The rheology modifying polymer or copolymer is a granulated powder of suitable particle size and is generally made from one or more unsaturated (di)carboxylic acids, half ester thereof, and other optional monomers.

La présente invention concerne des articles posologiques solides, tels que des comprimés pharmaceutiques, destinés à la libération contrôlée d'un composé souhaité, tel qu'une substance active. Ces articles sont directement comprimés à partir d'un mélange compressible, fluide, qui est constitué de ladite substance active, d'un polymère ou copolymère modificateur de rhéologie, légèrement réticulé, et d'un ou plusieurs excipients. Ledit polymère ou copolymère modificateur de rhéologie est une poudre granuleuse de taille particulaire convenable et est généralement constitué d'un ou plusieurs acides (di)carboxyliques insaturés, d'un semi-ester de ces derniers, ainsi que d'autres monomères optionnels.

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