Directly compressible formulations of azithromycin

Details Directly compressible formulations of azithromycin Directly compressible formulations of azithromycin

A - Human Necessities

61

K

A61K 31/7052 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2469246

The present invention relates to a dry blend, used for forming azithromycin tablets by direct compression, comprising non-dihydrate azithromycin and at least one pharmaceutically acceptable excipient. This invention also relates to an azithromycin tablet comprising non-dihydrate azithromycin and at least one pharmaceutically acceptable excipient. Preferably, the azithromycin tablet is formed by direct compressing the dry blend, of the present invention, to form said azithromycin tablet. Preferably, the azithromycin tablet, of the present invention, contains a dosage of 250 mgA, 500 mgA or 600 mgA of azithromycin. This invention further relates to an azithromycin tablet which is produced by forming a dry blend of a non-granulated azithromycin form A and at least one pharmaceutically acceptable excipient. The azithromycin tablet is then formed by formed by direct compressing the dry blend.

L'invention concerne un mélange sec, utilisé pour former des comprimés d'azithromycine par compression directe, comprenant de l'azithromycine non déshydratée, et au moins un excipient pharmaceutiquement acceptable. L'invention concerne également un comprimé d'azithromycine comprenant de l'azithromycine non déshydratée, et au moins un excipient pharmaceutiquement acceptable. De préférence, le comprimé d'azithromycine est formé par compression directe du mélange sec de l'invention, pour former ledit comprimé d'azithromycine. De préférence, le comprimé d'azithromycine de l'invention contient un dosage de 250 mgA, 500 mgA ou 600 mgA d'azithromycine. L'invention concerne également un comprimé d'azithromycine produit par la formation d'un mélange sec d'azithromycine non granulée de forme A, et d'au moins un excipient pharmaceutiquement acceptable. Ce comprimé d'azithromycine est ensuite formé par compression directe du mélange sec.

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