Dirofilaria immitis gp29 proteins, nucleic acid molecules...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/53 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 9/08 (2006.01) C12Q 1/28 (2006.01)

Patent

CA 2183963

The present invention relates to D. immitis Gp29 proteins, nucleic acid molecules having sequences that encode such proteins, antibodies raised against such proteins and inhibitors of D. immitis glutathione peroxidase. The present invention also includes methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitors. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasitic helminths, such as heartworm.

L'invention concerne des protéines Gp29 de D. Immitis, des molécules d'acide nucléique présentant des séquences codant ces protéines, des anticorps développés contre lesdites protéines ainsi que des inhibiteurs de glutathione peroxidase de D. Immitis. L'invention concerne également des procédés d'obtention de ces molécules d'acide nucléique, protéines, anticorps et inhibiteurs. En outre, l'invention inclut des compositions thérapeutiques comprenant ces molécules d'acide nucléique, protéines, anticorps et inhibiteurs, ainsi que leur utilisation pour protéger des animaux contre des maladies provoquées par des helminthes parasitaires tels que Dirofilaria Immitis.

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