Disaccharides for drug discovery

Details Disaccharides for drug discovery Disaccharides for drug discovery

C - Chemistry, Metallurgy

07

H

C07H 3/04 (2006.01) C07D 307/18 (2006.01) C07D 309/10 (2006.01) C07D 309/14 (2006.01) C07H 3/02 (2006.01)

Patent

CA 2483622

Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function and other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalised about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.

L'invention concerne des procédés de préparation de bibliothèques combinatoires de composés de disaccharide potentiellement actifs au plan biologique. Ces composés sont fonctionnalisés de diverses manières, en vue de varier la liposolubilité, la taille, la fonction et d'autres propriétés, dans le but particulier de découvrir des nouveaux composés médicamenteux ou de type médicamenteux, ou des composés présentant des propriétés utiles. L'invention porte également sur des intermédiaires, des procédés et des stratégies synthétiques pour la synthèse en solution ou en phase solide de disaccharides, fonctionnalisés de manière différentes autour du cycle sucre, comprenant l'addition de l'aromaticité et de la charge, ainsi que le placement de groupes utiles au plan pharmaceutique et d'isostères.

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