Discodermolide compounds, compositions containing same and...

C - Chemistry – Metallurgy – 07 – D

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C07D 309/30 (2006.01) A61K 31/365 (2006.01)

Patent

CA 2056412

Novel lactone compounds having immunomodulatory and antitumor activities, pharmaceutical compositions comprising such compounds, methods for the preparation of the novel compounds and compositions and methods of their use for therapeutic purposes are described. The new lactone compounds have the structure according to formula (I), wherein: R = -H, -A, -CH2-Q, -COA or -COZ, A = lower alkyl, Z = monocyclicaryl, Q = phenyl, tolyl or xylyl, X = -H, -A, -Z or -CH2-Z, and Y = -H, -A, -Z, -CH2-Z, -COA, -COZ, the acid-addition salts, the octahydro and 23,24-dihydro derivatives thereof.

Sont décrits des nouveaux composés de lactone présentant des activités immunomodulatrices et antitumorales, des compositions pharmaceutiques comprenant lesdits composés, des procédés de préparation des nouveaux composés ainsi que des compositions et leurs procédés d'utilisation à des fins thérapeutiques. Les nouveaux composés de lactone ont la structure de la formule (I), dans laquelle R = -H, -A, -CH2-Q, -COA or -COZ, A = alkyle inférieure, Z = aryl monocyclique, Q = phényle, tolyle ou xylyle, X = -H, -A, -Z ou -CH2-Z et Y = -H, -A, -Z, -CH2-Z, -COA, -COZ, leurs sels d'addition d'acide, leurs dérivés octahydro et 23,24-dihydro.

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