Discrimination between gnrh-i and gnrh-ii

Details Discrimination between gnrh-i and gnrh-ii Discrimination between gnrh-i and gnrh-ii

C - Chemistry, Metallurgy

07

K

C07K 7/23 (2006.01) A61K 38/09 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C07K 14/72 (2006.01) C07K 16/26 (2006.01)

Patent

CA 2421580

A peptide that comprises a modified GnRH decapeptide sequence which allows for a testosterone level that is essentially non-detectable after vaccination with the peptide in a suitable dosage and/or allows for a immunogenic response that allows for the effective discrimination between GnRH-I and GnRH-II and a method for the immunocastration of pigs and for the treatment of prostate cancers of humans

L'invention porte sur un peptide présentant une séquence modifiée du décapeptide GnRH produisant un niveau de testostérone pratiquement non détectable après vaccination par ledit peptide à dose adaptée, et/ou produisant une réponse immunogène permettant de distinguer entre le GnRH-I et le GnRH-II, et sur un procédé d'immunocastration de porcs.

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