Disease associated human autoantibodies specific for human...

Details Disease associated human autoantibodies specific for human... Disease associated human autoantibodies specific for human...

C - Chemistry, Metallurgy

12

N

C12N 9/08 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C07K 16/42 (2006.01) C12N 15/53 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2116453

2116453 9305072 PCTABS00020 Disease associated human autoantibodies specific for human thyroid peroxidase are disclosed. Novel organ-specific (TPO) human autoantibodies are disclosed which have been cloned, allowing definition of the autoantibody repertoire and the autoantigenic domains, encompassing a restricted immunodominant region on TPO recognized by patients with autoimmune thyroid disease. The novel compositions of the invention, their diagnostic and therapeutic applications, are, inter alia disclosed.

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