Disease model incorporation into an artificial immune system...

Details Disease model incorporation into an artificial immune system... Disease model incorporation into an artificial immune system...

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) C12N 5/078 (2010.01)

Patent

CA 2717197

The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and other materials in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system, coupled with disease models to provide a more complete representation of an immune response.

La présente invention concerne des procédés de construction dun système immunitaire artificiel intégré qui comprend des constructions cellulaires et tissulaires in vitro appropriées ou leurs équivalents pour imiter les tissus du système immunitaire des mammifères. Le système immunitaire artificiel peut être utilisé pour tester in vitro lefficacité de vaccins candidats et dautres matériaux. Il est par conséquent utile pour accélérer le développement de vaccins et pour tester des médicaments et des interactions chimiques avec le système immunitaire. Il peut être couplé avec des modèles de maladies pour fournir une représentation plus complète dune réponse immunitaire.

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