C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 29/00 (2006.01) C07K 14/47 (2006.01) C07K 14/515 (2006.01) C12Q 1/68 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2473218
An gene was identified as a RA disease susceptibility gene on Human Chromosome 8, the gene coding a protein that has an amino acid sequence shown in SEQ. ID NO.1 and that has such mutation that glycine is inserted as a 269th amino acid in the sequence. Moreover, it was found that mutation of the gene and the protein relate to onset of RA. Achieved is a method of evaluating with high accuracy the onset or onset possibility of RA by using the mutation.
L'invention concerne un gène renfermant l'acide aminé représenté par SEQ ID NO:1, avec une insertion de séquences répétitives de glycine en position de 269ème acide aminé dans la séquence. Ce gène est identifié comme sensible à la polyarthrite rhumatoïde sur le 8ème chromosome humain. En outre, il est établi clairement que la mutation du gène considéré et de sa protéine est liée à l'apparition de la maladie, ce qui permet d'établir un procédé d'évaluation de haute précision concernant l'apparition de la polyarthrite rhumatoïde ou le risque de son apparition, entre autres facteurs.
Komai Koichiro
Nakatsukasa Mikiko
Shiozawa Shunichi
Blake Cassels & Graydon Llp
Shiozawa Shunichi
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