Dispersible cimetidine tablets

Details Dispersible cimetidine tablets Dispersible cimetidine tablets

A - Human Necessities

61

K

167/237

A61K 31/415 (2006.01) A61K 9/20 (2006.01) A61K 47/32 (2006.01)

Patent

CA 1333156

There are described novel dispersible cimetidine tablets containing 30 to 90 % by weight of one of the polymorphous modifications of cimetidine A, B or C, 5 to 55 % by weight of one or more disintegrationg agents, 0.05 to 5.0 % by weight of a surfactant, such as sodium lauryl sulphate together with other common adjuvants. The process for the manufacture of dispersible cimetidine tablets is effected on the basis of known methods by granulating the ingredients and by compressing the granu- late to tablets. Dispersible tablets disintegrate when brought in contact with water at room tempera- ture within less than 1 minute to yield a fine dispersion, which facilitates the oral ap- plication. Therefore such tablets are particularly suitable for certain groups of patients, especiallly for the aged and children. Dispersible tablets containing cimetidine excell by their improved rate of dissolution and good bioavailability.

603116

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