A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/44 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2519589
A method is provided for treatment of an infective condition in a fluid- containing organ having a natural exterior orifice, such as the udder of a milk producing animal or an ear. The method comprises administering an antibacterial agent to the organ via the exterior orifice and administering in combination therapy with the antibacterial agent a second agent that is an anti-inflammatory agent, an analgesic and/or an antipyretic. The antibacterial agent and, optionally, the second agent, are administered as a pharmaceutical composition further comprising a vehicle that comprises an amphipathic oil that is water dispersible and ethanol insoluble, microcrystalline wax and a pharmaceutically acceptable non-aqueous carrier. Also provided is such a composition comprising the antibacterial agent and the second agent. The composition is readily dispersible in the fluid of the fluid-containing organ.
Selon ce procédé de traitement d'une condition infectieuse d'un organe qui contient un fluide et est pourvu d'un orifice extérieur naturel, tel que le pis d'une bête laitière ou une oreille, on administre un agent antibactérien à l'organe par l'orifice extérieur et on administre, dans un traitement combiné avec l'agent antibactérien, un second agent qui est un agent anti-inflammatoire, un anesthésique, un bloqueur du canal sodique, un analgésique et/ou un antipyrétique. L'agent antibactérien et, facultativement, le second agent sont administrés comme une composition pharmaceutique qui comprend en outre un excipient qui contient une huile amphipathique dispersible dans l'eau et insoluble dans l'éthanol, une cire microcristalline et un substrat non aqueux pharmaceutiquement acceptable. L'invention concerne également une composition de ce type qui contient l'agent antibactérien et le second agent. La composition se laisse aisément disperser dans le fluide contenu dans l'organe.
Britten Nancy J.
Burns John W.
Hallberg John W.
Waldron Niki A.
Watts Jeffrey L.
Pharmacia Corporation
Smart & Biggar
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