A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/223
A61K 31/48 (2006.01) A61K 9/20 (2006.01)
Patent
CA 1335573
There are described novel dispersible tablets of dihydroergotoxine or of acid addition salts thereof, containing 0.1 to 4 % by weight of dihydroergotoxine or its acid addition salts, 4 to 60 % by weight of one or more disintegrating agents, 0.8 to 10 % by weight of an organic acid and, optionally, 0.2 to 2 % by weight of an antioxidizing agent together with other common adjuvants. The process for the manufacture of dispersible tablets of dihydroergotoxine and of acid addition salts thereof is carried out on the basis of known methods by granulating the ingredients and by compressing the granulate to tablets. Dispersible tablets disintegrate within less than 1 minute when brought in contact with water at room temperature to yield a fine dispersion, which facilitates the oral applica- tion. Therefore such tablets are particulary suitable for the aged. Dispersible tablets containing dihydroergotoxine or acid addition salts thereof excell by their improved rate of dissolution and good bioavailability.
613266
Kofler Bojan
Kopitar Zdravko
Kovacic Mateja
Lampret Marija
Lenardic Andrej
N.sol.o. Lek Tovarna Farmacevtskih In Kemicnih Izdelkov
Sim & Mcburney
LandOfFree
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