Disphosphonic acid derivatives, processes for their...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/6506 (2006.01) A61K 31/675 (2006.01) C07D 233/54 (2006.01) C07F 9/6503 (2006.01)

Patent

CA 2056438

- 1 - A b s t r a c t The present invention concerns novel disphosphonates having the general formula I Image (I), in which Het represents a heterocyclic five-membered ring with 2-4 heteroatoms which is substituted, if desired, and which can also be partially hydrogenated, R1-R7 each denote, independently of each other, hydrogen or C1-C5 alkyl, X = denotes hydrogen, OH or the group -NR8R9, in which R8 and R9 should each be, independently of each other, hydrogen or C1-C5 alkyl, m and n denote, independently of each other, 0, 1 or 2, as well as their pharmacologically safe salts and optically active forms.

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