Display of viral proteins as ligands for cell-surface receptor

Details Display of viral proteins as ligands for cell-surface receptor Display of viral proteins as ligands for cell-surface receptor

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 47/48 (2006.01) C07K 14/15 (2006.01) C12N 7/04 (2006.01) C12N 15/10 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) C12N 15/867 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2328597

The invention relates to the targeted delivery of substances to cells. The invention provides a method for selecting at least one mutant protein derived from a viral protein as a ligand capable of binding to a cell-surface receptor, comprising displaying at least one mutant of said protein on the surface of a micro-organism expressing said protein, further comprising selecting at least one such a mutant micro-organism for its capacity to bind to said receptor further comprising incorporating said protein in a virus-like particle or gene-delivery vehicle allowing targeting of said virus-like particle or gene-delivery vehicle to cells carrying said receptor.

L'invention se rapporte à l'administration ciblée de substances à des cellules. Elle se rapporte notamment à une méthode de sélection d'au moins une protéine mutante dérivée d'une protéine virale et utilisée en tant que ligand susceptible de se lier à un récepteur de surface cellulaire. Ladite méthode consiste à présenter au moins un mutant de ladite protéine à la surface d'un micro-organisme exprimant ladite protéine, puis à sélectionner au moins un tel micro-organisme mutant pour sa capacité à se lier audit récepteur, à introduire ensuite ladite protéine dans une particule de type virus ou un véhicule d'administration de gène de façon à cibler ladite particule de type virus ou ledit véhicule d'administration de gène sur des cellules portant ledit récepteur.

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