Display vectors and methods and uses thereof

Details Display vectors and methods and uses thereof Display vectors and methods and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/79 (2006.01)

Patent

CA 2711806

I The present invention relates, in one aspect, to a vector comprising (a) a first polynucleotide capable of encoding a first (poly)peptide comprising at least one cysteine residue, and (b) a second polynucleotide capable of encoding a second (poly)peptide which is a cell surface anchor comprising at least one cysteine residue, wherein the vector is operable in a eukaryotic host cell to express and to cause or allow the attachment of said first (poly)peptide to said second (poly)peptide by formation of a disulfide bond between said cysteine residues comprised within said first (polypeptide and said second (poly)peptide, respectively, wherein said first (poly)peptide is exhibited at the surface of a eukaryotic host cell.

Sous l'un de ses aspects, la présente invention porte sur un vecteur comprenant (a) un premier polynucléotide apte à coder pour un premier (poly)peptide comprenant au moins un reste de cystéine; et (b) un second polynucléotide apte à coder pour un second (poly)peptide qui est une ancre de surface cellulaire comprenant au moins un reste de cystéine. Le vecteur est apte à fonctionner dans une cellule hôte eucaryote pour exprimer et pour provoquer ou permettre la fixation du premier (poly)peptide sur le second (poly)peptide par formation d'une liaison disulfure entre les restes de cystéine compris respectivement dans le premier (poly)peptide et le second (poly)peptide, le premier (poly)peptide étant présent à la surface d'une cellule hôte eucaryote.

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