C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) C12N 15/09 (2006.01) C12Q 1/00 (2006.01) G01N 33/50 (2006.01) C07K 14/47 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2584297
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
L'invention concerne des animaux transgéniques, ainsi que des compositions et des procédés ayant trait à la caractérisation de la fonction génique. Spécifiquement, l'invention concerne des souris transgéniques présentant des disruptions dans les gènes ci-après : PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 ou PRO23370. De telles études et caractérisations in vivo peuvent conduire à des identifications précieuses et à la découverte d'agents thérapeutiques et/ou de traitements utiles pour la prévention, l'amélioration ou l'infléchissement de maladies ou de dysfonctionnements en rapport avec des disruptions géniques, tels que troubles neurologiques ; troubles cardiovasculaires, endothéliaux ou angiogènes ; anomalies oculaires ; troubles de l'immunologie ; troubles oncologiques ; anomalies ou troubles du métabolisme osseux ; troubles du métabolisme des lipides ; ou anomalies du développement.
Byers-Horner Allison Anne
Combs Katherin
Desauvage Frederic
Ding Zhiyong
French Dorothy
Genentech Inc.
Lexicon Genetics Incorporated
Lexicon Pharmaceuticals Inc.
Smart & Biggar
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