Dissolution cell and method for determining the in- vitro...

Details Dissolution cell and method for determining the in- vitro... Dissolution cell and method for determining the in- vitro...

G - Physics

01

N

150/9

G01N 1/00 (2006.01) B01F 1/00 (2006.01) G01N 13/00 (2006.01) G01N 33/15 (2006.01) G01N 37/00 (2006.01) B01F 7/00 (2006.01) G01N 35/00 (2006.01)

Patent

CA 1274159

ABSTRACT OF THE DISCLOSURE The invention provides a dissolution cell and method for determining the in-vitro release rate of a drug in suitable form, e.g. a suppository. The cell includes a solid rectangular top wall and a pair of trapezoidal side walls extending from the top wall. Disposed between the side walls are a pair of end walls and a bottom wall each comprised of a wire mesh material. The bottom wall and end walls can be made in one piece. The top wall has an opening and a flanged extension which can be coupled to a suitable rotating device. In use the cell containing the drug is rotated in a suitable dissolution medium and the rate of release of the drug is determined by analyzing the amount of drug released to the dissolution medium at predetermind intervals.

511997

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