Dissolution liquid for drug in iontophoresis

Details Dissolution liquid for drug in iontophoresis Dissolution liquid for drug in iontophoresis

A - Human Necessities

61

K

A61K 47/00 (2006.01) A61K 9/70 (2006.01) A61N 1/30 (2006.01)

Patent

CA 2178445

A drug held or supported by an interface comprising a porous matrix is dissolved with a drug dissolution liquid containing a humectant, and the drug is trans- dermally delivered by iontophoresis. The humectant in- cludes e.g. glycerin and other polyhydric alcohols, sugar alcohols, proline and other amino acids and acidic mucopolysaccharides. The concentration of the humectant may be about 1 to 50% by weight, and the concentration of proline or other amino acid or its salt may be about 1 to 30% by weight. The drug includes (1) a physiologi- cally active peptide or protein with a molecular weight of 100 to 30,000 or (2) a nonpeptide physiologically active compound with a molecular weight of 100 to 1,000.

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