Dissolvable backing layer for use with a transmucosal...

Details Dissolvable backing layer for use with a transmucosal... Dissolvable backing layer for use with a transmucosal...

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2523784

A dissolvable backing layer for use with transmucosal drug delivery devices includes a dissolvable hydrophilic region and a non-hydrophilic region that inhibits or slows migration of water, drugs, other active agents, or other molecules through the backing layer. The non-hydrophilic region can be a disperse phase of gaseous voids, droplets of a hydrophobic liquid, solid particles of a hydrophobic material, or water insoluble particles that are not necessarily hydrophobic. In the alternative, the non-hydrophilic region may comprise a continuous layer or component that is readily dispersible upon dissolving of the hydrophilic region. The backing layers may be used within any transmucosal delivery device used to delivery drugs or other active agents across a mucosal surface.

L'invention concerne une couche de support soluble utilisable avec des dispositifs d'administration de médicaments par voie transmuqueuse. La couche de support soluble comprend une région hydrophile soluble et une région non hydrophile qui inhibe ou ralentit la migration de l'eau, des médicaments ou d'autres agents actifs ou molécules au travers de la couche de support. La région non hydrophile peut être une phase dispersée de vides gazeux, des gouttelettes d'un liquide hydrophobe, des particules solides d'un matériau hydrophobe, ou des particules insolubles dans l'eau non nécessairement hydrophobes. En variante, la région non hydrophile peut comprendre une couche continue ou un constituant facilement dispersable après dissolution de la région hydrophile. Les couches de support peuvent s'employer dans un quelconque dispositif d'administration par voie transmuqueuse utilisé pour administrer des médicaments ou autres agents actifs au travers d'une muqueuse.

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