Disubstituted chalcone oximes as selective agonists of...

C - Chemistry – Metallurgy – 07 – C

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C07C 251/40 (2006.01) A61K 31/15 (2006.01) A61K 31/343 (2006.01) A61K 31/353 (2006.01) A61K 31/382 (2006.01) A61K 31/4704 (2006.01) A61K 31/498 (2006.01) A61P 11/00 (2006.01) A61P 17/06 (2006.01) C07D 215/22 (2006.01) C07D 241/42 (2006.01) C07D 307/81 (2006.01) C07D 307/87 (2006.01) C07D 311/58 (2006.01) C07D 335/06 (2006.01)

Patent

CA 2552090

Compounds of the formula where the variables are as defined in the specification, are useful for preventing or treating emphysema and related pulmonary conditions of mammals and other diseases and conditions which are responsive to RAR.gamma. agonist retinoids, such as skin related diseases, including but not limited to acne and psoriasis.

L'invention porte sur des composés de la formule dans laquelle les variables sont telles que définies dans la spécification, qui sont utilisés pour prévenir ou traiter l'emphysème et les états pulmonaires associés chez les mammifères et autres maladies et états répondant aux agonistes des récepteurs des rétinoïdes RAR¿??, comme les maladies de la peau, y compris mais de manière non limitative, l'acné et le psoriasis.

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