Disubstituted ureas and thioureas derivatives

Details Disubstituted ureas and thioureas derivatives Disubstituted ureas and thioureas derivatives

C - Chemistry, Metallurgy

07

D

C07D 317/30 (2006.01) A61K 31/17 (2006.01) A61K 31/335 (2006.01) A61K 31/385 (2006.01) A61K 31/44 (2006.01) C07C 275/32 (2006.01) C07C 323/44 (2006.01) C07D 317/28 (2006.01) C07D 319/06 (2006.01) C07D 339/00 (2006.01) C07D 339/06 (2006.01) C07D 339/08 (2006.01) C07D 405/06 (2006.01) C07D 405/10 (2006.01) C07D 409/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2061447

ABSTRACT DISUBSTITUTED UREAS AND THIOUREAS The invention provides new ureas and thioureas derivatives of general formula (I) Image (I) wherein m is zero, 1 or 2; n is 1, 2 or 3; Q is oxygen or sulphur; X and Y, being the same, are oxygen or sulphur; A is a) a C1-C10 saturated or unsaturated, branched or un- branched hydrocarbon chain, unsubstituted or sub- stituted by 1 to 4 substituents independently chosen from halogen, C1-C6 alkyl, trihalo-C1-C3 alkyl and C1-C6 alkoxy; b) a C3-C7 cycloalkyl ring unsubstituted or substi- tuted by 1 to 4 substituents independently chosen from halogen, C1-C6 alkyl, trihalo-Cl-C3 alkyl and C1-C6 alkoxy; c) an aryl group unsubstituted or substituted by one to four substituents independently chosen from halogen, C1-C6 alkyl, trihalo-C1-C3 alkyl, hydroxy, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylsulfonyl and C1-C4 di-alkylamino; Abstract d) an aryl group substituted by two adjacent sub- stituents forming a methylenedioxy group and optionally by 1 to 3 substituents as defined above under c); or e) an aryl group substituted by an imidazolyl group, in its turn optionally substituted by C1-C4 alkyl; each of R1 and R2, independently, is C1-C6 alkyl; or R1 and R2, taken together, are a C2-C4 alkylene chain in which each carbon atom can be optionally substituted by 1 or 2 substituents independently chosen from halogen and C1-C4 alkyl; B is an aryl group unsubstituted or substituted by 1 to 4 substituents independently chosen from halogen, C1-C6 alkyl, trihalo-C1-C3 alkyl, C1-C6 alkoxy, C1-C6 alkyl- thio, and C1-C6 alkylsulfonyl; and the pharmaceutically acceptable salts thereof, which are useful as therapeutic agents such as for the prevention of coronary heart disease and as antidyslipidaemic agents.

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