Disubstituted ureas as kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 403/12 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2592743

The invention relates to compounds of the formula (I), their use as kinase inhibitors, new pharmaceutical formulations comprising said compounds, said compounds for use in the diagnostic or therapeutic treatment of warm-blooded animals, especially humans, their use in the treatment of diseases or for the manufacture of pharmaceutical formulations useful in the treatment of diseases that respond to modulation of kinase activity, methods of treatment comprising administration of said compounds to a warm-blooded animal, especially a human, and processes for the manufacture of said compounds.

L'invention concerne des composés de formule (I) ; leur utilisation en tant qu'inhibiteurs de kinase ; des nouvelles formulations pharmaceutiques comprenant ces composés ; lesdits composés à utiliser pour le diagnostic ou le traitement thérapeutique d'animaux à sang chaud, en particulier les êtres humains ; leur utilisation dans le traitement de maladies ou pour la fabrication de formulations pharmaceutiques utiles dans le traitement de maladies qui répondent à la modulation de l'activité kinase. L'invention concerne également des méthodes de traitement consistant à administrer lesdits composés à un animal à sang chaud, en particulier un être humain, et des procédés de fabrication desdits composés.

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