Dithienyl alkyl amines and process for their production

C - Chemistry – Metallurgy – 07 – D

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260/328.6, 260/2

C07D 409/14 (2006.01) C07D 295/08 (2006.01) C07D 333/16 (2006.01) C07D 333/20 (2006.01)

Patent

CA 1096380

ABSTRACT OF THE DISCLOSURE The present invention provides compounds of the general formula Image I wherein Image has either the structure Image or the structure Image , Alk represents a straight or branched C1-C5- alkylene group and Y a C3-C7-cycloalkyl radical, a methylene- dioxy-benzyl radical, a benzyl radical which is singly, doubly or triply substituted by C1-C4-alkoxy groups, or it represents a straight or branched C1-C6-alkyl radical substituted by a di-C1-C4-alkyl-amino group, a morpholino group, or it represents the radical Image wherein R represents a C1-C4-alkyl group and the hydroxyl group can also be acylated by a C2-C6-alkanoyl group or wherein the group -NHY represents the radical Image and R' represents a phenyl radical, a phenyl radical, which is Aingly or doubly substituted by C1-C4-alkyl groups, C1-C4 alkoxy groups or halogen atoms, a C1-C6-alkyl radical, a C1-C4-oxy-alkyl radical or a phenyl-C1-C4-alkyl radical, which can also be sub- stituted in the phenyl ring by 1 to 3 C1-C4-alkoxy groups or the radical -NH-CH(R)-CH(OH)-C6H5 (wherein R has the meaning defined above) when Alk consists of 2 to 5 carbon atoms or a pharmaceuti- cally acceptable salt thereof. These compounds are pharmaceuti- cally effective, particularly in the case of heart and circulation disorders. In particular, they cause an increase of the peri- pheral and cerebral blood flow.

294846

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