C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/55 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01)
Patent
CA 2375878
This invention provides novel dithiepino[6,5-b]pyridines of formulae (I) and (II). These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.
L'invention concerne de nouveaux dithiépino[6,5-b]pyridines correspondant aux formules (I) et (II). Ces composés servent d'antagonistes de canaux calciques présentant une activité cardiovasculaire, antiasthmatique et antibronchoconstrictive. Cette invention concerne également des compositions pharmaceutiques ainsi que des méthodes permettant de prévenir et de traiter des troubles tels que l'hypersensibilité, l'allergie, l'asthme, le bronchospasme, la dysménorrhée, le spasme oesophagien, le glaucome, l'accouchement prématuré, les infections des voies urinaires, les troubles de la motilité gastro-intestinale ou les troubles cardiovasculaires.
Bullington James L.
Dodd John H.
Hall Daniel A.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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