A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/325 (2006.01) A61K 31/145 (2006.01) A61K 31/185 (2006.01) A61K 31/198 (2006.01) A61K 31/40 (2006.01) A61K 45/06 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2147881
Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplastry restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.
Des dithocarboxylates, et en particulier des dithiocarbamates, bloquent l'expression induite d'une molécule d'adhésion à la surface de cellules endothéliales VCAM-1, et se révèlent donc utiles dans le traitement de maladies cardiovasculaires, y compris l'athérosclérose, la resténose post-angioplastie, les maladies des artères coronaires et l'angine de poitrine, ainsi que des maladies inflammatoires non cardiovasculaires faisant l'objet d'une médiation par VCAM-1.
Alexander R. Wayne
Medford Russel M.
Offermann Margaret K.
Emory University
Mbm & Co.
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