Dithiochrome, an insulin-binding molecule with glucose...

Details Dithiochrome, an insulin-binding molecule with glucose... Dithiochrome, an insulin-binding molecule with glucose...

A - Human Necessities

61

K

A61K 31/28 (2006.01) A61K 33/00 (2006.01) A61K 35/12 (2006.01) A61K 35/74 (2006.01) C12P 1/00 (2006.01)

Patent

CA 2064036

2064036 9101738 PCTABS00003 A material obtained by: (i) lysing a eukaryotic cell mass and then combining the lysate obtained with a mixture of an aqueous buffer and an organic solvent; (ii) separating the organic phase from the water phase; (iii) subjecting the delipidated water phase extract to an insulin affinity chromatography matrix, a sulfhydryl exchange chromatography matrix, a C4,8,18- or phenyl reverse phase chromatography matrix, or an anion exchange chromatography matrix; (iv) and eluting the chromatography matrix to obtain a material capable of binding with insulin. This material may be used to treat patients suffering from elevated blood glucose or suboptimal glucose kinetics. An adduct of this compound with insulin may be used to treat patients for type I diabetes.

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