Dithiolane derivatives

Details Dithiolane derivatives Dithiolane derivatives

C - Chemistry, Metallurgy

07

D

167/207, 260/278

C07D 339/06 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 1334408

Novel dithiolane derivatives are produced by reacting glyoxal sodium bisulfite adduct with amine compounds in the presence of acids and then with dithiolates. The invention relates to a dithiolane derivative represented by the general formula (I) Image wherein X represents C2-C7 alkylcarbonyl group; benzoyl group or benzoyl group substituted with 1 to 3 groups selected from the group consisting of halogen atom, C1-C4 alkyl group and C1-C4 alkoxy group; Y represents C2-C7 alkylcarbonyl group, C2-C7 alkoxycarbonyl group or cyano group, and R represents di(C1-C4 alkyl)amino group, morpholino group, 4-C1-C4 alkylpiperazino group or piperidino group. The dithiolane derivatives can activate liver functions and are effective for treatment and prophylaxis or hepatitis and other hepatic disorders.

608474

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