Dithiolylidene acetamide derivatives

Details Dithiolylidene acetamide derivatives Dithiolylidene acetamide derivatives

C - Chemistry, Metallurgy

07

D

C07D 339/06 (2006.01) A61K 31/385 (2006.01)

Patent

CA 2250523

Disclosed are dithiolylidene acetamide derivatives represented by the following formula: Image wherein R1 and R2 may be the same or different and each independently represent a hydrogen atom or an alkyl group, or salts thereof; and pharmaceuticals containing them as effective ingredients. The dithiolylidene acetamide derivatives and their salts show AGE formation inhibitory action and are useful as preventives and therapeutics for diabetic complications.

Divulgation concernant des dérivés de dithiolylidèneacétamide - représentés par la formule Image , dans laquelle R1 et R2 peuvent être identiques ou différents et représenter chacun indépendamment un atome d'hydrogène ou un groupe alkyle - ou des sels de ces dérivés, ainsi que des produits pharmaceutiques qui en renferment comme ingrédients actifs. Les dérivés de dithiolylidèneacétamide et leurs sels montrent une activité inhibitrice de la formation d'AGE et sont utiles comme agents de prévention et de traitement des complications diabétiques.

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