Diurea derivatives

Details Diurea derivatives Diurea derivatives

A - Human Necessities

61

K

A61K 31/4025 (2006.01) A61K 31/155 (2006.01) A61K 31/195 (2006.01) A61P 19/00 (2006.01) A61P 21/00 (2006.01) C07D 207/26 (2006.01) C07D 211/98 (2006.01) C07D 215/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2551566

The present invention relates to novel diurea derivatives that block intracellular signal transduction and thereby inhibit the production of pro- inflammatory cytokines, especially interleukin-2 (IL-2) and/or induce apoptosis in activated T-cells. It further discloses such a compound for use as a medicament, the use of said compound for the manufacturing of a medicament for the treatment of immune disorders which benefit from inhibition of production of IL-2 and other pro-inflammatory cytokines and/or induction of apoptosis in activated T-cells, a pharmaceutical composition comprising said compound and a method of treatment comprising administration of a pharmaceutically effective amount of said compound. A compound of the general formula I.

L'invention concerne de nouveaux dérivés de diurée qui bloquent la transduction intracellulaire du signal et inhibent ainsi la production des cytokines pro-inflammatoires, en particulier de l'interleukine-2 (IL-2) et/ou induisent l'apoptose dans les lymphocytes-T activés. L'invention concerne également un tel composé destiné à être utilisé comme médicament, l'utilisation dudit composé pour la production d'un médicament destiné au traitement de troubles immunitaires, réagissant favorablement à l'inhibition de la production d'IL-2 et d'autres cytokines pro-inflammatoires et/ou à l'induction de l'apoptose dans les lymphocytes T activés, une composition pharmaceutique contenant ledit composé et une méthode de traitement comprenant l'administration d'une dose pharmaceutiquement efficace dudit composé. Composé de formule générale (I) : (I)

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