Divalent hapten derivatives, process for preparing and use...

Details Divalent hapten derivatives, process for preparing and use... Divalent hapten derivatives, process for preparing and use...

C - Chemistry, Metallurgy

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C07D 239/62 (2006.01) C07G 99/00 (2009.01) C07D 239/64 (2006.01) C07D 473/08 (2006.01) G01N 33/531 (2006.01) G01N 33/542 (2006.01) G01N 33/546 (2006.01) G01N 33/78 (2006.01) G01N 33/94 (2006.01)

Patent

CA 1272193

Abstract Divalent hapten derivatives used for the determination of drugs having the formula I A-X-A I where A is a bonded hapten moiety and X is a bifunctional spacer having the formula II (B)m-Y-(CH2)n-Z-(CH2)n-Y-(B)m II where m is independently 0 or 1, B is (CH2)n', wherein n' is an integer from 1-4, or CO(CH2)n", wherein n" is an integer from 2-4; Y is independently -CONH-, -NHCO-, -OOC-, -COO-, -O-, -S-, or -NR-, wherein R is hydrogen or an aliphatic radical; n is an integer from 1-10; and Z is an organic residue containing one or more hydrophilic atoms, and a process for preparing such derivatives.

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