C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 337/06 (2006.01) A61K 31/17 (2006.01) A61K 31/175 (2006.01) A61K 47/48 (2006.01) A61P 1/12 (2006.01) C07C 335/20 (2006.01) C08G 65/334 (2006.01)
Patent
CA 2718676
Provided herein are divalent hydrazide-polyethylene glycol conjugates that inhibit the ion transport activity of a cystic fibrosis transmembrane conductance regulator (CFTR). The conjugates described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, secretory diarrhea.
La présente invention concerne des conjugués dhydrazide-polyéthylène glycol bivalents qui inhibent lactivité de transport ionique dun régulateur de la conductance transmembranaire de la mucoviscidose (CFTR). Les conjugués décrits dans le présent document sont utiles pour le traitement de maladies, de troubles, et de séquelles de maladies, de troubles, et de conditions qui sont associés à une activité anormalement accrue du CFTR, par exemple, la diarrhée sécrétoire.
Sonawane Nitin D.
Verkman Alan S.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Regents Of The University Of California
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