Divalproex sodium dosage forms and a process for their...

Details Divalproex sodium dosage forms and a process for their... Divalproex sodium dosage forms and a process for their...

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2431415

The present invention is directed to a new process for granulating valproate compounds, such as divalproex sodium, in which the compound is melted in the absence of a binder and admixed with one or more excipients to produce granules. The resulting dosage forms have an increased drug loading factor in the range of 75 w/w% to 90 w/w%.

La présente invention concerne un nouveau procédé de granulation de composés de valproate, tels que le divalproex de sodium, dans lequel le composé est mélangé en l'absence de liant puis mélangé à nouveau avec un ou plusieurs excipients pour produire des granules. Les formes posologiques résultantes présentent un facteur de charge du médicament plus important qui se situe dans la fourchette comprise entre 75 % en poids et 90 % en poids.

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