Dmbt1 as a clinical marker and uses thereof

Details Dmbt1 as a clinical marker and uses thereof Dmbt1 as a clinical marker and uses thereof

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2542021

The current invention provides methods for determining the estrogenic activity of a compound, which includes contacting an estrogen-responsive system having a gene under the control of a DMBT1 regulatory sequence with a test compound and determining how the test compound affects expression of the gene. The invention further provides for determining the progestogenic activity of a compound, which includes contacting an estrogen- and progesterone-responsive system having a gene under the control of a DMBT1 regulatory sequence with an estrogenic activity and a test compound and determining how the test compound effects expression of the gene. Nucleic acids and cell-based systems that include a portion of the DMBT1 regulatory sequence useful for these methods are also provided.

L'invention concerne des procédés de détermination de l'activité oestrogénique d'un composé. On met en contact un système à réaction oestrogénique ayant un gène contrôlé par séquence régulatrice DMBT1 et un composé d'essai, puis on détermine la manière dont le composé d'essai affecte l'expression du gène. L'invention concerne également la détermination de l'activité oestrogénique d'un composé. On met en contact un système à réaction oestrogénique et progestéronique ayant un gène contrôlé par séquence régulatrice DMBT1 à activité oestrogénique et un composé d'essai, puis on détermine la manière dont le composé d'essai affecte l'expression du gène. L'invention concerne en outre des acides nucléiques et des systèmes cellulaires qui comportent une partie de la séquence régulatrice DMBT1, utiles pour la mise en oeuvre des procédés considérés.

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