C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) C07K 14/31 (2006.01) C12N 9/52 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) C12Q 1/18 (2006.01)
Patent
CA 2063316
X-8419 ABSTRACT The invention provides a gene encoding a novel PBP2A penicillin binding protein isolated from the methicillin resistant S. aureus strain 27R. The invention further provides soluble forms of PBP2A proteins lacking the transmembrane association region yet retain their active site configuration of the PBP2A protein. The invention also provides a method of assaying for agents useful against methicillin resistant staphylococcus strains by creating a kinetically inert complex between a support- immobilized transition metal ion and a modified soluble form of the PBP2A protein incorporating a chelating agent. The invention further provides a cell free method of assaying for agents which bind the PBP2A-27R protein.
Blaszczak Larry C.
Skatrud Paul L.
Smith Michele C.
Wu Chyun-Yeh E.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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