C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/202, 195/1.1
C12N 5/00 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 1339935
The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.
582338
Dagle John M.
Eder Paul S.
Walder Joseph A.
Walder Roxanne Y.
Ridout & Maybee Llp
University Of Iowa Research Foundation
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